ANTIBODIES AGAINST THE REPETITIVE EPITOPE OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM FALCIPARUM (NANP) 50 AND MALARIA ATTACKS IN AN ENDEMIC AREA OF BURKINA FASO
J.B. Ouédraogo, N. Coulibaly, A.R. Gbary, S.O. Coulibaly & T.R. Guiguemdé
This study was carried out in the medical centres of three villages near the town of Bobo-Dioulasso (Burkina Faso) during the maximum malaria transmission period (June to December 1992). 554 patients having a clinical profile of a malaria attack were recruited into the study.
In 362 (65.3 %) of them, the diagnosis of malaria was confirmed by microscopic examination. ELISA was carried out by elution of blood spots on filter paper of 554 patients.
The average of anti-sporozoite antibody concentrations were higher in patients with no parasitemia (46.4 + 38.3 U ml-1) than in patients with parasitemia (26.2 + 24.4 U ml-1). Antibody concentrations were significantly reduced when the parasitemia increased (p < 0.001).
The antibody rate increased regularly with age. The mean age necessary to have a high rate was 13 years old and this level became very high on and after 19 years old.
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