Malaria N° 6 - Subject N° 5

PLASMODIUM FALCIPARUM SENSITIVITY TO VARIOUS ANTIMALARIALS IN ADZOPE (CÔTE D’IVOIRE)
T.A.K. Agjetey, G. Nekouressi, E.I.H. Menan, N.N. Assavo, S. Diarra, G.B. Koua, N.G.F. Nebavi, J. Ouhon, L.K. Penali & M. Kone

SUMMARY
A study of in vivo Plasmodium falciparum sensitivity to currently available antimalarials was carried out in 100 patients aged from 0 to 15 years between August and September 1993 at Adzopé in the Côte d’Ivoire.
Chloroquine was administered in accordance with the standard 7 day WHO protocol administered a dose of 25 mg/kg in divided doses over 3 days.
Out of 100 patients treated, 68 apyrexic patients (68%) harboured RII type chloroquine resistant strains with the exception of 7 patients who became febrile at D7.
Second line therapy with amodiaquine at a dosage of 30mg/kg over 3 days showed that 9.38% of chloroquine resistant strains were also resistant to amodiaquine.
The sulfadoxine-pyrimethamine combination used as third line treatment at a dose of 1 tab/20kg did not reveal any cases of resistance.

KEY-WORDS: Plasmodium falciparum, Chloroquine, Amodiaquine, Chemo-resistance, Sulfadoxine-pyrimethamine, Adzopé, Côte d’Ivoire