Malaria N° 10 - Subject N° 3

THE THERAPEUTIC EFFICACY OF AMODIAQUINE, SULFADOXINE-PYRIMETHAMINE COMBINATION AND QUININE IN SENEGAL
O. Gaye

SUMMARY
In 1995 Senegal took on a national programme to combat malaria, the major strategy of which was the correct management of patients with falciparum malaria. This programme may be compromised, however, by emergence of chemoresistance. For this reason, monitoring the chemosensitivity of Plasmodium falciparum and proposing alternative management regimens to those used is an important feature of the programme.
We describe below the results of three studies examining the efficacy of amodiaquine as an alternative to chloroquine in cases of allergy, of sulfadoxine-pyrimethamine used if chloroquine treatment has failed, and of quinine, reserved for serious cases of malaria.