Malaria N° 1 - Subjects N° 4

DRUG RESISTANCE: ITS APPAREANCE AND MECHANISMS IN WEST AFRICA
by O. Walker

SUMMARY
Since drug resistant P. falciparum appeared on the scene, there has been increasing difficulty with treatment and prophylaxis of the disease. Until recebtly, chloroquine was the drug of choice for the treatment and prophylaxis of malaria in different part of the world, because of it's efficacy, relative lack of side effects and availability. Neverless, this is no more so because of the spread of resistant strains of P. falciparum to drug round the world....

DRUG RESISTANCE: ITS APPAREANCE IN EAST AND SOUTHERN AFRICA, CHEMORESISTANCE MECHANISMS AND THE IMPLICATIONS OF THIS FINDINGS FOR CONTROL
by B.L. Sharp

SUMMARY
One of the major obstacles facing malaria control is the resistance Plasmodium falciparum develops to anti-malarial drugs. Resistance to chloroquine was first detected in both South America and S.E. Asia in the late 1950's from both Kenya and Tanzania. During the 1980's, it spread throughout southern Africa...