Malaria N° 8 - Subject N° 7

MALARIA PATHOGENESIS: CYTOKINE VARIATION IN PATIENTS FROM ASYMPTOMATIC TO SYMPTOMATIC STAGE OF PLASMODIUM FALCIPARUM MALARIA INFECTION.
Running title: Cytokines in malaria
J-B. Ouédraogo, S.O. Coulibaly, A.R. Gbary, H.O. Zampa, F. Veas & T.R. Guiguemdé

SUMMARY
IL1ß, IL6 and TNFa were analysed in asymptomatic and symptomatic patients infected with malaria. Serum cytokines assays were performed by radioimmunoassay. IL1ß level was significantly higher (p = 0.008) in asymptomatic stages (geometric mean = 896 pg/ml) than in symptomatic stages (geometric mean = 685.4 pg/ml). No significant variation was observed with TNFa and IL6 but a positive correlation between these two cytokines at fever stage was found (r = 0,850 P = 0,02). IL1ß level was decreased in non-severe malaria infected patients when clinical signs as fever appeared. However TNFa and IL6 are produced but their levels remained unchanged in non-severe malaria.