THE IN-VITRO SENSITIVITY OF PLASMODIUM FALCIPARUM TO CHLOROQUINE & SULFADOXINE-PYRIMETHAMINE (Fansidar) IN BURUNDI (Nyanza-Lac)
In Nyanza-Lac where malaria is hyperendemic, an in vivo study of chloroquine and fansidar sensitivity is carried out in two primary schools.
The follow up is performed in 755 children from 6 to 15 years old.
392 with parasites in their blood (plasmodic indice 52 per cent) are notified in that asymptomatic scolar population.
Among 400 children having taken 25 mg per kg body weight of chloroquine, 210 are harboring parasites in their blood.
In 41 children involved in the study (parasitemia more than a 1000 parasites per µl of falciparum only; 36 (88 %) have no parasite in their blood on the first day following the end of the 3 days of treatment.
Five children are positive until the end of experiment with an increased parasitemia (12 % of resistancy).
In 355 children having taken a single dose of Fansidar (1 tablet per 20 kg body weight), 182 are positive.
On the 46 children involved in the study, 39 are cleared of their parasites at the rate of 85 % on the 4th day following the treatment and at the rate of 96 % on the end of experiment.
2 children (4 %) resistent to treatment are however of low parasitemy.
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