Malaria N° 9 - Subject N° 6

ANTIMALARIAL CHEMOPROPHYLAXIS IN AFRICA
M. Kombila & A. Same-Ekobo

SUMMARY
The widespread use of antimalarial drugs for prophylaxis with the inevitably poor compliance and resulting underdosing has provided the selection pressure of emergence of resistance to many drugs, especially Amino-4-quinoleines, Proguanil and Pyrimethamine. It also leads to debilitating the acquired protecting immunity and subsequently the increase in cases of severe malaria. In that context, only some people are required to take chemoprophylaxis and new prophylactic drugs are need to prevent falciparum malaria in areas where Chloroquine, Pyrimethamine or Proguanil are no longer useful.