Malaria N° 4 - Subject N° 5

CHANGE IN PARASITIC DENSITY FOLLOWING TREATMENT WITH INJECTABLE DILUTED QUININE ADMINISTRERED INTRARECTALLY IN CHILDREN WITH MALARIA
S.H. Boureima & M. Idrissa

SUMMARY
A study of clinical and parasitological efficacy of diluted injectable quinine administered intrarectally was carried out in the Biomedical Laboratory of the National School of Public Health (ENSP).
The aforementioned study belongs in the context of a study for an alternative effective treatment in order to limit the accidents inherent in the practice of the intramuscular administration of quinine in children. All of the subjects included in the study were suffering from malaria due to Plasmodium falciparum; over three days they rceived an intra-rectal administration every 12 hours of quinine bichlorhydrate (Quinimax) injectable diluted in 2 cc of distilled water at a dose of 20 mg/kg body weight. Blood sample were taken before each administration and over the remaining days and for up to 7 days.
The technique was found to be very effective both from the clinical and laboratory standpoint and the administered medicine was very well tolerated by patients thus proving that the intrarectal method of administration of diluted quinine can offer an effective alternative treatment for malaria in materially difficult situations.

KEY-WORDS: Changes in parasitic density, Diluted intrarectally administered quinine